Medical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Immunol. 2018 May 28;9:1170. doi: 10.3389/fimmu.2018.01170. eCollection 2018.
Tumor necrosis factor (TNF) is widely accepted as a tumor-suppressive cytokine its ubiquitous receptor TNF receptor 1 (TNFR1). The other receptor, TNFR2, is not only expressed on some tumor cells but also on suppressive immune cells, including regulatory T cells and myeloid-derived suppressor cells. In contrast to TNFR1, TNFR2 diverts the tumor-inhibiting TNF into a tumor-advocating factor. TNFR2 directly promotes the proliferation of some kinds of tumor cells. Also activating immunosuppressive cells, it supports immune escape and tumor development. Hence, TNFR2 may represent a potential target of cancer therapy. Here, we focus on expression and role of TNFR2 in the tumor microenvironment. We summarize the recent progress in understanding how TNFR2-dependent mechanisms promote carcinogenesis and tumor growth and discuss the potential value of TNFR2 in cancer treatment.
肿瘤坏死因子 (TNF) 被广泛认为是一种肿瘤抑制细胞因子，其广泛表达的受体为 TNF 受体 1（TNFR1）。另一个受体 TNFR2 不仅在一些肿瘤细胞上表达，也在抑制性免疫细胞上表达，包括调节性 T 细胞和髓源性抑制细胞。与 TNFR1 不同，TNFR2 将具有抑瘤作用的 TNF 转化为促进肿瘤生长的因子。TNFR2 直接促进某些类型的肿瘤细胞增殖。同时，它还激活免疫抑制细胞，支持免疫逃逸和肿瘤发展。因此，TNFR2 可能成为癌症治疗的一个潜在靶点。本文主要关注 TNFR2 在肿瘤微环境中的表达和作用。我们总结了近年来对 TNFR2 依赖性机制促进致癌作用和肿瘤生长的理解方面的进展，并讨论了 TNFR2 在癌症治疗中的潜在价值。
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