伤口愈合与银屑病和多发性硬化症的关系。
The Relationship of Wound Healing with Psoriasis and Multiple Sclerosis.
作者信息
Morhenn Vera B
机构信息
Department of Dermatology, San Francisco VA Medical Center, San Francisco, California.
出版信息
Adv Wound Care (New Rochelle). 2018 Jun 1;7(6):185-188. doi: 10.1089/wound.2017.0773.
Abstract
Better understanding of wound healing could lead to improved treatment(s) of multiple sclerosis (MS) and psoriasis (Pso). New concepts in the events of wound healing, such as the roles of the innate and adaptive immune systems, have generated targets for treating these debilitating diseases. That in MS and Pso defective wound healing is responsible for the diseases' progression has not been hypothesized to date. Impaired initiation of wound repair by oligodendrocyte precursor cells or oligodendrocytes may play a role in MS, and a lack of inhibition of the proliferative phase in wound healing may explain the pathophysiology involved in Pso.
摘要
对伤口愈合有更深入的了解可能会带来针对多发性硬化症（MS）和银屑病（Pso）的更好治疗方法。伤口愈合过程中的新概念，如先天免疫系统和适应性免疫系统的作用，已催生出治疗这些使人衰弱疾病的靶点。迄今为止，尚未有人提出在MS和Pso中，有缺陷的伤口愈合是导致疾病进展的原因。少突胶质前体细胞或少突胶质细胞对伤口修复起始的损害可能在MS中起作用，而伤口愈合增殖期缺乏抑制可能解释了Pso所涉及的病理生理学。
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