Bisson J L, Argyle D J, Argyle S A
The Royal (Dick) School of Veterinary Studies and the Roslin Insitute, University of Edinburgh, Edinburgh, UK.
Vet Comp Oncol. 2018 Sep;16(3):301-310. doi: 10.1111/vco.12406. Epub 2018 Jun 12.
Bacterial infection following cancer chemotherapy-induced neutropenia is a serious cause of morbidity and mortality in human and veterinary patients. Antimicrobial prophylaxis is controversial in the human oncology field, as any decreased incidence in bacterial infections is countered by patient adverse effects and increased antimicrobial resistance. Comprehensive guidelines exist to aid human oncologists in prescribing antimicrobial prophylaxis but similar recommendations are not available in veterinary literature. As the veterinarian's role in antimicrobial stewardship is increasingly emphasized, it is vital that veterinary oncologists implement appropriate antimicrobial use. By considering the available human and veterinary literature we present an overview of current clinical practices and are able to suggest recommendations for prophylactic antimicrobial use in veterinary cancer chemotherapy patients.
癌症化疗引起的中性粒细胞减少症后的细菌感染是人类和兽医患者发病和死亡的严重原因。在人类肿瘤学领域，抗菌预防存在争议，因为细菌感染发病率的任何降低都会被患者的不良反应和抗菌药物耐药性增加所抵消。有综合指南帮助人类肿瘤学家开具抗菌预防药物，但兽医文献中没有类似的建议。随着兽医在抗菌药物管理中的作用越来越受到重视，兽医肿瘤学家实施适当的抗菌药物使用至关重要。通过参考现有的人类和兽医文献，我们概述了当前的临床实践，并能够为兽医癌症化疗患者预防性使用抗菌药物提出建议。
