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声门神经源性肿瘤:神经鞘瘤的一个极不常见的部位。

Glottic neurogenic tumor: A highly uncommon site for schwannomas.

作者信息

Singh Shuchita, Kumar Rakesh, Roy Maitrayee, Mridha Asit Ranjan

机构信息

Department of Otorhinolaryngology, All India Institute of Medical Sciences, New Delhi, India.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

出版信息

J Cancer Res Ther. 2018 Apr-Jun;14(3):687-689. doi: 10.4103/jcrt.JCRT_878_14.

Abstract

Schwannomas are benign encapsulated neurogenic tumors, arising from Schwann cells embedded in neurilemal sheath as multinucleated syncytial network. Head and neck schwannomas account for 25%-45% of all schwannomas, majority developing in parapharyngeal space. Laryngeal schwannoma in itself is a rarity, and a glottic origin further complicates its diagnosis. To the best of our knowledge, this is the second case of glottic schwannoma being reported in medical literature. Symptomatology is attributable to mass effect of a slow-growing laryngeal tumor, ranging from sore throat to stridor. The gold standard method for their excision is still debatable. For small tumors, endoscopic or direct laryngoscopic approach is preferred, but for large glottic tumors, external approach is advocated for better exposure and facilitating mucosal grafting. Index case is being presented not only for its rare site of origin, but also to stress on the importance of meticulous histopathological examination to advocate appropriate treatment.

摘要

施万细胞瘤是良性的有包膜神经源性肿瘤,由嵌入神经鞘膜的施万细胞形成多核合胞体网络产生。头颈部施万细胞瘤占所有施万细胞瘤的25% - 45%,大多数发生在咽旁间隙。喉施万细胞瘤本身较为罕见,而起源于声门则使其诊断更加复杂。据我们所知,这是医学文献中报道的第二例声门施万细胞瘤病例。症状归因于生长缓慢的喉部肿瘤的占位效应,范围从咽痛到喘鸣。其切除的金标准方法仍存在争议。对于小肿瘤,首选内镜或直接喉镜检查方法,但对于大的声门肿瘤,主张采用外部入路以更好地暴露并便于黏膜移植。报告该索引病例不仅是因为其罕见的起源部位,还在于强调细致的组织病理学检查对倡导适当治疗的重要性。

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