Bhardwaj Minakshi, Gupta Prajwala
Department of Pathology, Post Graduate Institute of Medical Education and Research, Dr. RML Hospital, New Delhi, India.
J Cancer Res Ther. 2018 Apr-Jun;14(3):706-708. doi: 10.4103/0973-1482.179522.
Carcinoma ex pleomorphic adenoma (Ca ex PA) is defined as a carcinoma arising from a primary (de novo) or recurrent benign pleomorphic adenoma. The most common histological subtype is adenocarcinoma, not otherwise specified, salivary duct carcinoma, mucoepidermoid carcinoma, and adenoid cystic carcinoma (ACC). Few case reports of de novo dedifferentiation in ACC are there in the literature, mostly involving minor salivary glands. The dedifferentiated adenoid cystic carcinoma arising in a pleomorphic adenoma of the parotid gland has not been reported earlier. The present case highlights this rare histological subtype seen in Ca ex PA and the role of extensive histopathological examination and immunohistochemistry.
多形性腺瘤恶变（Ca ex PA）定义为源自原发性（新发）或复发性良性多形性腺瘤的癌。最常见的组织学亚型为未另行特指的腺癌、涎腺导管癌、黏液表皮样癌和腺样囊性癌（ACC）。文献中关于ACC新发去分化的病例报告较少，大多涉及小涎腺。腮腺多形性腺瘤中发生的去分化腺样囊性癌此前未见报道。本病例突出了在Ca ex PA中所见的这种罕见组织学亚型以及广泛组织病理学检查和免疫组化的作用。
