Ide Fumio, Mishima Kenji, Yamada Hiroyuki, Saito Ichiro
Department of Pathology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.
Head Neck Pathol. 2009 Jun;3(2):159-62. doi: 10.1007/s12105-009-0108-3. Epub 2009 Feb 28.
There is a considerable variation in the histologic subtype of epithelial malignancies among carcinoma ex pleomorphic adenomas (CXPA) and virtually any known carcinoma entity can develop. To our knowledge, adenoid cystic carcinoma (AdCC) ex PA is quite rare despite the fact that de novo AdCC is the fourth most common salivary gland malignancy. We describe a new case of AdCC ex PA in the parotid gland of a 62 year-old woman. In our patient, there was a short interval of time between parotidectomy and local recurrence and rapid development of distant metastases. Although most of the reported cases are considered low-grade, evidence is presented here that AdCC can take the form of a high-grade malignancy in PA.
多形性腺瘤恶变（CXPA）的上皮性恶性肿瘤组织学亚型存在相当大的差异，几乎任何已知的癌实体都可能发生。据我们所知，多形性腺瘤恶变后的腺样囊性癌（AdCC）相当罕见，尽管原发性腺样囊性癌是第四常见的涎腺恶性肿瘤。我们描述了一例62岁女性腮腺发生的多形性腺瘤恶变后的腺样囊性癌新病例。在我们的患者中，腮腺切除术后至局部复发及远处转移快速发展的时间间隔较短。尽管大多数报道的病例被认为是低级别肿瘤，但本文有证据表明，多形性腺瘤恶变后的腺样囊性癌可以呈现高级别恶性肿瘤的形式。
