1,4-二氧六环调控的一氧化碳和硼氢化钠对胺的无催化剂甲基化反应
1,4-Dioxane-Tuned Catalyst-Free Methylation of Amines by CO and NaBH.
作者信息
Guo Zhiqiang, Zhang Bo, Wei Xuehong, Xi Chanjuan
机构信息
Scientific Instrument Center, Shanxi University, Taiyuan, 030006, P. R. China.
MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
出版信息
ChemSusChem. 2018 Jul 20;11(14):2296-2299. doi: 10.1002/cssc.201801037. Epub 2018 Jul 3.
A catalyst-free reductive functionalization of CO with amines and NaBH was developed. The N-methylation of amines was carried out with CO as a C building block and 1,4-dioxane as the solvent. Notably, the six-electron reduction of CO to form the methyl group occurred simultaneously with formation of the C-N bond to give the N-methylated amine.
开发了一种以胺类和硼氢化钠对一氧化碳进行无催化剂还原官能化的方法。胺的N-甲基化反应以一氧化碳作为碳源、1,4-二氧六环作为溶剂进行。值得注意的是，一氧化碳的六电子还原形成甲基的过程与C-N键的形成同时发生，从而得到N-甲基化胺。
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