Xia Wenkai, Wang Tianyl, Sun Dong, Mao Weidong, Xie Xiangcheng
Eur J Gynaecol Oncol. 2016 Aug;37(4):530-538.
Estrogen signal medicated by estrogen receptor (ER), which is involved in various diseases related to steroid hormone, such as cancer. A number of association studies have focused on ESR2 polymorphisms to investigate the relationship with cancer risk. However, the results are inconsistent and inconclusive. To examine this controversy, 33 studies were enrolled for the pooled analysis for three poly-morphisms (rs3020450, rs4986938, and rs1256049) in cancer risk using odds ratios (ORs) with 95% confidence intervals (CIs). Regarding rs4986938, A allele was associated with decreased breast cancer. Ethnicity subgroup analysis observed a decreased risk in both Asian and Caucasian descendent. Regarding rs1256049, cancer type subgroup analysis revealed a significant association with increased prostate and endometrial cancer risk. rs3020450 was not associated with cancer risk in any model. Further studies for clarifying the roles of ESR2 polymorphisms in cancer risk seem of vital importance.
由雌激素受体（ER）介导的雌激素信号参与了多种与甾体激素相关的疾病，如癌症。许多关联研究聚焦于ESR2基因多态性，以探究其与癌症风险的关系。然而，结果并不一致且尚无定论。为了审视这一争议，我们纳入了33项研究，对三种多态性（rs3020450、rs4986938和rs1256049）与癌症风险进行汇总分析，采用比值比（OR）及95%置信区间（CI）。对于rs4986938，A等位基因与乳腺癌风险降低相关。种族亚组分析显示，亚洲和高加索后裔的风险均降低。对于rs1256049，癌症类型亚组分析显示，其与前列腺癌和子宫内膜癌风险增加显著相关。在任何模型中，rs3020450均与癌症风险无关。进一步研究以阐明ESR2基因多态性在癌症风险中的作用似乎至关重要。
