Ahn S H, Roh H J, Cho H J, You S G, Lee S H, Kwon Y S
Eur J Gynaecol Oncol. 2016 Aug;37(4):549-553.
Non-gestational choriocarcinoma (NGCO) is a rare primary ovarian cancer with poor prognosis. It is important to distinguish it from gestational ovarian choriocarcinoma (GCO), because there are different treatment options. However, it is difficult to distinguish the two types by routine histologic, ultrastructural, or immunohistochemical examination. The authors present NGCO in a 41-year-old woman, which was confirmed by DNA polymorphism analysis. All tested microsatellite markers had identical DNA profiles with the same allelic sizes between tumor and normal myometrium of the patient, indicating that both tissues originated from the same person. The results confirmed that the tumor was non-gestational in origin. Although the tumor was large, the authors performed hand- assisted laparoscopic surgical (HALS) staging. After three cycles of combination chemotherapy and surgery, the patient has not had any evidence of disease 48 months after treatment. This case demonstrates the usefulness of HALS staging and DNA polymorphism analysis in NGCO.
非妊娠性绒毛膜癌（NGCO）是一种罕见的原发性卵巢癌，预后较差。将其与妊娠性卵巢绒毛膜癌（GCO）区分开来很重要，因为治疗方案不同。然而，通过常规组织学、超微结构或免疫组化检查很难区分这两种类型。作者报告了一名41岁女性的NGCO病例，该病例通过DNA多态性分析得以确诊。所有检测的微卫星标记在患者肿瘤组织和正常子宫肌层之间具有相同的DNA图谱和等位基因大小，表明这两种组织来源于同一个人。结果证实该肿瘤起源于非妊娠性。尽管肿瘤较大，但作者进行了手辅助腹腔镜手术（HALS）分期。经过三个周期的联合化疗和手术，患者在治疗后48个月没有任何疾病迹象。该病例证明了HALS分期和DNA多态性分析在NGCO中的作用。
