DZNE-German Center for Neurodegenerative Diseases, Otfried-Müller Str. 23, D-72076 Tübingen, Germany.
University of Tübingen, Institute for Ophthalmic Research, Center for Ophthalmology, Elfriede-Aulhorn-Str. 7, D-72076 Tübingen, Germany.
Biol Chem. 2018 Jun 27;399(7):637-642. doi: 10.1515/hsz-2018-0132.
Leucine-rich repeat kinase 2 (LRRK2) is a multi-domain protein and its mutations can lead to Parkinson's disease. Recent studies on LRRK2 and homologue proteins have advanced our mechanistic understanding of LRRK2 regulation. Here, we summarize the available data on the biochemistry and structure of LRRK2 and postulate three possible layers of regulation, translocation, monomer-dimer equilibrium and intramolecular activation of domains.
富含亮氨酸重复激酶 2（LRRK2）是一种多功能蛋白，其突变可导致帕金森病。最近对 LRRK2 和同源蛋白的研究增进了我们对 LRRK2 调控机制的理解。在此，我们总结了 LRRK2 的生物化学和结构的现有数据，并提出了三个可能的调控层，即易位、单体-二聚体平衡和分子内结构域激活。
