Annamalai Shiva K, Kapur Navin K
The CardioVascular Center, Tufts Medical Center, Boston, Massachusetts.
Catheter Cardiovasc Interv. 2018 Jun;91(7):1192-1193. doi: 10.1002/ccd.27671.
Rising urine NGAL and serum creatinine after 48 hr are potentially useful in predicting persistent creatinine increase in patients with contrast-induced AKI. Urinary NGAL may allow for early identification of a high-risk cohort following PCI. Future studies are needed to determine whether renal biomarkers are affected by clinical variables, such as heart failure acute mechanical circulatory support (AMCS) and whether they can be used to identify patients who would benefit from either AMCS reno-protection during PCI remains unknown.
48小时后尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和血清肌酐升高可能有助于预测造影剂所致急性肾损伤（AKI）患者的肌酐持续升高。尿NGAL可能有助于早期识别PCI术后的高危人群。未来需要开展研究以确定肾脏生物标志物是否受临床变量（如心力衰竭、急性机械循环支持（AMCS））的影响，以及它们是否可用于识别在PCI期间能从AMCS肾脏保护中获益的患者，目前这些仍不清楚。
