Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043, Orbassano, Turin, Italy.
Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043, Orbassano, Turin, Italy.
Biochimie. 2018 Oct;153:220-231. doi: 10.1016/j.biochi.2018.06.006. Epub 2018 Jun 9.
A growing bulk of evidence suggests that cholesterol oxidation products, known as oxysterols, are potentially involved in the pathogenesis of major chronic diseases, including atherosclerosis, Alzheimer's disease, and inflammatory bowel disease. Oxysterols are involved in various key steps of these complex processes, mainly thanks to their ability to act through up-regulation of oxidative stress, inflammation, and cell toxicity. This review summarizes the current knowledge of the effects induced by these compounds on cells, after their accumulation in the arterial wall, brain, and intestine. This evidence might help to develop innovative strategies to counteract the progression of these chronic inflammatory human diseases.
越来越多的证据表明，胆固醇氧化产物，被称为氧化固醇，可能与包括动脉粥样硬化、阿尔茨海默病和炎症性肠病在内的主要慢性疾病的发病机制有关。氧化固醇参与这些复杂过程的各种关键步骤，主要得益于它们通过上调氧化应激、炎症和细胞毒性来发挥作用的能力。这篇综述总结了这些化合物在积累到动脉壁、大脑和肠道后对细胞产生的影响的现有知识。这一证据可能有助于制定创新策略来对抗这些慢性炎症性人类疾病的进展。
