Wang Wei
Department of Endocrinology, Tianjin First Center Hopital, Tianjin, China,
Kidney Blood Press Res. 2018;43(3):931-937. doi: 10.1159/000490472. Epub 2018 Jun 7.
BACKGROUND/AIMS: The aim of this study was to investigate the therapeutic effect of different doses of tripterygium glycosides (TG) in the treatment of diabetic nephropathy (DN). The effect of TG on blood lipids and safety were also evaluated.
Sixty patients with type 2 DN were randomly divided into three groups (n=20 per group): low-dose (30 mg/day TG), double-dose (60 mg/day TG) and control (placebo) groups, all three times daily for 6 months. The levels of triglycerides, total cholesterol, urinary protein, plasma albumin and serum tumour necrosis factor (TNF)-α were compared between the three groups.
After treatment, urinary protein and TNF-α level significantly decreased in patients in the treatment groups, compared with the control group. This decrease was significantly larger in the double-dose group than in the low-dose group. However, there was no significant decrease in triglycerides and total cholesterol in the two treatment groups. Furthermore, plasma albumin was lower in the treatment groups than in the control group.
The double dose of TG has improved clinical efficacy, compared with the low dose, and the same safety profile.
背景/目的：本研究旨在探讨不同剂量雷公藤多苷（TG）治疗糖尿病肾病（DN）的疗效。同时评估TG对血脂的影响及安全性。
将60例2型糖尿病肾病患者随机分为三组（每组n = 20）：低剂量组（30 mg/天TG）、双倍剂量组（60 mg/天TG）和对照组（安慰剂），均每日三次，治疗6个月。比较三组患者甘油三酯、总胆固醇、尿蛋白、血浆白蛋白和血清肿瘤坏死因子（TNF）-α水平。
治疗后，与对照组相比，治疗组患者尿蛋白和TNF-α水平显著降低。双倍剂量组的降低幅度明显大于低剂量组。然而，两个治疗组的甘油三酯和总胆固醇水平无显著降低。此外，治疗组的血浆白蛋白低于对照组。
与低剂量相比，双倍剂量TG具有更好的临床疗效，且安全性相同。
