2',3'-环核苷酸3'-磷酸水解酶在兔丙烯酰胺诱导的视神经病变中的作用
2',3'-Cyclic nucleotide 3'-phosphohydrolase in acrylamide-induced optic neuropathy in rabbit.
作者信息
Ohki K, Machi N, Matsushima S, Mizuno A
出版信息
Jpn J Ophthalmol. 1985;29(1):110-4.
PMID:2989596
Abstract
The in vivo effects of acrylamide on the nerve tissues of the rabbit optic pathway were examined. The optic nerve of acrylamide-treated rabbits showed inflammatory changes and degeneration. The decrease of myelin was observed with myelin stain. The activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase (EC.3.1.4.37) which is firmly bound to myelin was markedly diminished by acrylamide intoxication.
摘要
研究了丙烯酰胺对家兔视通路神经组织的体内效应。经丙烯酰胺处理的家兔视神经出现炎症变化和变性。用髓鞘染色观察到髓鞘减少。与髓鞘紧密结合的2',3'-环核苷酸3'-磷酸水解酶（EC.3.1.4.37）的活性因丙烯酰胺中毒而显著降低。
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