Lv Qing, Du Ailian, Wei Wenshi, Li Yuanyuan, Liu Gailing, Wang Xiao Ping
Department of Neurology, TongRen Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Department of Neurology, Huadong Hospital and Shanghai Medical College, Fudan University, Shanghai, China.
Front Neurosci. 2018 May 29;12:360. doi: 10.3389/fnins.2018.00360. eCollection 2018.
Damage to memory circuits may lead to dementia symptoms in Alzheimer's disease (AD) and Parkinson's disease dementia (PDD). Recently, deep brain stimulation (DBS) has been shown to be a novel means of memory neuromodulation when critical nodes in the memory circuit are targeted, such as the nucleus basalis of Meynert (NBM) and fornix. Potential memory improvements have been observed after DBS in patients with AD and PDD. DBS for the treatment of AD and PDD may be feasible and safe, but it is still preliminary. In this review, we explore the potential role of DBS for the treatment of dementia symptoms in AD and PDD. Firstly, we discuss memory circuits linked to AD and PDD. Secondly, we summarize clinical trials and case reports on NBM or fornix stimulation in AD or PDD patients and discuss the outcomes and limitations of these studies. Finally, we discuss the challenges and future of DBS for the treatment of AD and PDD. We include the latest research results from Gratwicke et al. (2017) and compare them with the results of previous relevant studies, and this would be a worthy update of the literature on DBS for dementia. In addition, we hypothesize that the differences between AD and PDD may ultimately lead to different results following DBS treatment.
记忆回路受损可能会导致阿尔茨海默病（AD）和帕金森病痴呆（PDD）出现痴呆症状。最近，当针对记忆回路中的关键节点（如梅纳特基底核（NBM）和穹窿）进行深部脑刺激（DBS）时，已被证明是一种记忆神经调节的新方法。在AD和PDD患者中，DBS治疗后已观察到潜在的记忆改善。DBS用于治疗AD和PDD可能是可行且安全的，但仍处于初步阶段。在本综述中，我们探讨DBS在治疗AD和PDD痴呆症状方面的潜在作用。首先，我们讨论与AD和PDD相关的记忆回路。其次，我们总结了AD或PDD患者中NBM或穹窿刺激的临床试验和病例报告，并讨论这些研究的结果和局限性。最后，我们讨论DBS治疗AD和PDD的挑战和未来。我们纳入了Gratwicke等人（2017年）的最新研究结果，并将其与之前相关研究的结果进行比较，这将是DBS治疗痴呆症文献的一次有价值的更新。此外，我们假设AD和PDD之间的差异最终可能导致DBS治疗后出现不同的结果。
