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在一名因垂体腺瘤导致中枢性库欣病的患者中，通过促肾上腺皮质激素释放因子对血浆促肾上腺皮质激素的刺激不一致。

Inconsistent stimulation of plasma ACTH through corticotropin-releasing factor in a patient with central Cushing's disease due to pituitary adenoma.

作者信息

Rohrmoser B, Lüdecke D K, Scriba P C

出版信息

Klin Wochenschr. 1985 May 15;63(10):475-7. doi: 10.1007/BF01731496.

DOI:10.1007/BF01731496
PMID:2989613
Abstract

Three uncommon findings were observed in a case of Cushing's disease due to macroadenoma: no suppression of plasma ACTH during an 8-mg dexamethasone test, a negative corticotropin-releasing factor test, and a normal X-ray of the sella turcica. Despite these findings, the diagnosis of pituitary was confirmed Cushing's syndrome by computerized tomography and a transphenoidal operation.

摘要

在一例因大腺瘤导致的库欣病病例中观察到三个不常见的发现

8毫克地塞米松试验期间血浆促肾上腺皮质激素（ACTH）未被抑制、促肾上腺皮质激素释放因子试验为阴性以及蝶鞍X线检查正常。尽管有这些发现，但通过计算机断层扫描和经蝶窦手术确诊为垂体库欣综合征。

相似文献

1
Inconsistent stimulation of plasma ACTH through corticotropin-releasing factor in a patient with central Cushing's disease due to pituitary adenoma.在一名因垂体腺瘤导致中枢性库欣病的患者中，通过促肾上腺皮质激素释放因子对血浆促肾上腺皮质激素的刺激不一致。
Klin Wochenschr. 1985 May 15;63(10):475-7. doi: 10.1007/BF01731496.
2
The corticotropin-releasing factor stimulation test. An aid in the evaluation of patients with Cushing's syndrome.促肾上腺皮质激素释放因子刺激试验。对库欣综合征患者评估的一种辅助手段。
N Engl J Med. 1984 Mar 8;310(10):622-6. doi: 10.1056/NEJM198403083101004.
3
Circulating adrenomedullin is increased in patients with corticotropin-dependent Cushing's syndrome due to pituitary adenoma.因垂体腺瘤导致的促肾上腺皮质激素依赖性库欣综合征患者，其循环血中的肾上腺髓质素水平升高。
Metabolism. 2000 Jun;49(6):760-3. doi: 10.1053/meta.2000.6241.
4
How early can one diagnose Cushing's disease? An early diagnosis in a case of prepubertal Cushing's disease.库欣病能多早被诊断出来？一例青春期前库欣病的早期诊断。
J Pediatr Endocrinol Metab. 2014 Nov;27(11-12):1043-7. doi: 10.1515/jpem-2014-0230.
5
Bilateral and simultaneous sinus petrosus inferior catheterization in patients with Cushing's syndrome: plasma-immunoreactive-ACTH-concentrations before and after administration of CRF.库欣综合征患者双侧同时进行岩下窦插管：注射促肾上腺皮质激素释放因子（CRF）前后血浆免疫反应性促肾上腺皮质激素（ACTH）浓度
Horm Metab Res Suppl. 1987;16:66-7.
6
Plasma ACTH-response to the corticotropin releasing factor in patients with Cushing's disease. Comparison with the lysine-vasopressin test.
Metabolism. 1984 May;33(5):478-81. doi: 10.1016/0026-0495(84)90151-3.
7
[Localization of an ACTH-producing pituitary microadenoma using bilateral and simultaneous catheterization of the inferior petrosal sinus].
Rofo. 1988 Mar;148(3):275-8. doi: 10.1055/s-2008-1048192.
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Biochemical assessment of Cushing's disease in patients with corticotroph macroadenomas.促肾上腺皮质激素细胞大腺瘤患者库欣病的生化评估
J Clin Endocrinol Metab. 1998 May;83(5):1619-23. doi: 10.1210/jcem.83.5.4845.
9
[Evaluation of the accuracy of inferior petrosal sinus sampling in the differential diagnosis of ACTH-dependent Cushing's syndrome].[岩下窦采血在促肾上腺皮质激素依赖性库欣综合征鉴别诊断中的准确性评估]
Orv Hetil. 2007 May 6;148(18):843-7. doi: 10.1556/OH.2007.28048.
10
Corticotropin-releasing factor (CRF) stimulation test in normal subjects and patients with Cushing's syndrome.正常受试者和库欣综合征患者的促肾上腺皮质激素释放因子（CRF）刺激试验。
Exp Clin Endocrinol. 1989 Apr;93(1):19-28. doi: 10.1055/s-0029-1210832.

引用本文的文献

1
The corticotropin-releasing factor test in the diagnosis of ectopic ACTH secretion.促肾上腺皮质激素释放因子试验在异位促肾上腺皮质激素分泌诊断中的应用
West J Med. 1987 May;146(5):614-5.

本文引用的文献

1
Corticotropin releasing factor: a new tool for the differential diagnosis of Cushing's syndrome.促肾上腺皮质激素释放因子：库欣综合征鉴别诊断的新工具。
J Clin Endocrinol Metab. 1983 Jul;57(1):227-9. doi: 10.1210/jcem-57-1-227.
2
Corticotropin releasing factor (CRF)-stimulation test in normal controls and patients with disturbances of the hypothalamo-pituitary-adrenal axis.正常对照者及下丘脑-垂体-肾上腺轴功能紊乱患者的促肾上腺皮质激素释放因子（CRF）刺激试验
Klin Wochenschr. 1982 Dec 15;60(24):1485-91. doi: 10.1007/BF01716099.
3
Effect of synthetic ovine corticotropin-releasing factor. Dose response of plasma adrenocorticotropin and cortisol.
合成羊促肾上腺皮质激素释放因子的作用。血浆促肾上腺皮质激素和皮质醇的剂量反应。
J Clin Invest. 1983 Mar;71(3):587-95. doi: 10.1172/jci110804.
4
New hypothalamic hormone, corticotropin-releasing factor, specifically stimulates the release of adrenocorticotropic hormone and cortisol in man.新的下丘脑激素，促肾上腺皮质激素释放因子，特异性地刺激人体中促肾上腺皮质激素和皮质醇的释放。
Lancet. 1982 Apr 24;1(8278):921-2. doi: 10.1016/s0140-6736(82)91929-8.
5
Preoperative lateralization of ACTH-secreting pituitary microadenomas by bilateral and simultaneous inferior petrosal venous sinus sampling.
N Engl J Med. 1985 Jan 10;312(2):100-3. doi: 10.1056/NEJM198501103120207.
6
Paradoxical ACTH response to glucocorticoids in Cushing's disease.库欣病中促肾上腺皮质激素对糖皮质激素的反常反应。
N Engl J Med. 1977 Oct 27;297(17):904-7. doi: 10.1056/NEJM197710272971703.
7
Plasma ACTH and cortisol responses to TRF, vasopressin or hypoglycemia in cushing's disease and nelson's syndrome.库欣病和纳尔逊综合征中血浆促肾上腺皮质激素（ACTH）和皮质醇对促甲状腺激素释放因子（TRF）、血管加压素或低血糖的反应。
J Clin Endocrinol Metab. 1977 Feb;44(2):361-8. doi: 10.1210/jcem-44-2-361.