Gene Alterations in Small for Gestational Age (SGA) Children.

BACKGROUND

Small for gestational age children (SGA) is born on term with BW and or BL of -2.0 standard deviation score (SDS). SGA children have an increased risk of being short, developing DM, and cardiovascular and cerebrovascular disease. Often defects of are the cause of SGA. Most frequently affected part of the IGF1R gene is the exon 2.

AIM

To investigate whether the exon 2 of the gene is affected in the SGA children.

PATIENTS AND METHODS

A cohort of 100 SGA children born in term was evaluated for alterations in gene. Their anthropometric parameters, IGF1 serum concentrations and IGF1 SDS values were analysed. The molecular analysis of IGF1R gene was performed by PCR restriction-site analysis and followed by direct sequencing of conspicuous fragments.

RESULTS

Within our cohort, 64 SGA children were with short stature (height SDS -3.25 ± 0.90 SDS), and 36 were with normal height for their age and sex, (H SDS was 0.20 ± 1.1 SDS). None of these children had microcephaly (occipitofrontal circumference -0.70 ± 1.01 SDS vs 0.06 ± 0.56 SDS in SGA children with normal height) or dysmorphic features. The IGF1 serum concentrations and IGF1 SDS values of all children were within normal range. Only one child had lower normal serum IGF1 concentration. No alterations in exon 2 of gene were detected.

CONCLUSIONS

The genetic analysis of the exon 2 of the gene did not detect any gene defects in the analysed patients. The putative genetic defect in those children affects other parts of the gene or another gene (s), or yet unidentified factors.