关于G4 DNA与人类蛋白质相互作用的数据集。

Data set on G4 DNA interactions with human proteins.

作者信息

Vlasenok M, Levchenko O, Basmanov D, Klinov D, Varizhuk A, Pozmogova G

机构信息

Research and Clinical Center for Physical Chemical Medicine, 119435 Moscow, Russia.

出版信息

Data Brief. 2018 Mar 9;18:348-359. doi: 10.1016/j.dib.2018.02.081. eCollection 2018 Jun.

DOI:10.1016/j.dib.2018.02.081

PMID:29896522

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5996148/

Abstract

Guanine-rich DNA/RNA fragments can fold into G-quadruplexes (G4s) - non-canonical four-strand secondary structures. The article contains data on quadruplex interaction with human proteins. Binding of three topologically different G4 structures to more than 9000 human proteins was analyzed. Physicochemical methods were used to verify the results.The dataset was generated to identify the protein targets for DNA quadruplex structures for the purpose of better understanding the role of the structures in gene expression regulation. Presented data include functional interpretation of obtained gene lists, visualized with Cytoscape.

摘要

富含鸟嘌呤的DNA/RNA片段可以折叠成G-四链体（G4s）——非经典的四链二级结构。本文包含四链体与人类蛋白质相互作用的数据。分析了三种拓扑结构不同的G4结构与9000多种人类蛋白质的结合情况。采用物理化学方法验证结果。生成该数据集的目的是识别DNA四链体结构的蛋白质靶点，以便更好地理解这些结构在基因表达调控中的作用。所呈现的数据包括对获得的基因列表的功能解读，并通过Cytoscape进行可视化展示。