Marcus Adrian Julian, Iezhitsa Igor, Agarwal Renu, Vassiliev Pavel, Spasov Alexander, Zhukovskaya Olga, Anisimova Vera, Mohd Ismail Nafeeza
Centre for Neuroscience Research, Faculty of Medicine, Universiti Teknologi MARA, Malaysia.
Volgograd State Medical University, Research Institute of Pharmacology, Volgograd, Russia.
Data Brief. 2018 Mar 8;18:523-554. doi: 10.1016/j.dib.2018.03.019. eCollection 2018 Jun.
This data is to document the intraocular pressure (IOP) lowering activity of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats. Effects of single drop application of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on IOP in ocular normotensive rats are presented at 3 different concentrations (0.1%, 0.2% and 0.4%). Time course of changes in IOP is presented over 6 h period post-instillation. The IOP lowering activities of test compounds were determined by assessing maximum decrease in IOP from baseline and corresponding control, duration of IOP lowering and area under curve (AUC) of time versus response curve. Data shown here may serve as benchmarks for other researchers studying IOP-lowering effect of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds and would be useful in determining therapeutic potential of these test compounds as IOP lowering agents.
这些数据旨在记录咪唑并[1,2-a]苯并咪唑和嘧啶并[1,2-a]苯并咪唑化合物在正常眼压大鼠眼中降低眼压（IOP）的活性。研究了咪唑并[1,2-a]苯并咪唑和嘧啶并[1,2-a]苯并咪唑化合物以3种不同浓度（0.1%、0.2%和0.4%）单次滴眼对正常眼压大鼠眼压的影响。记录了滴药后6小时内眼压变化的时间过程。通过评估眼压相对于基线和相应对照的最大降幅、眼压降低的持续时间以及时间-反应曲线的曲线下面积（AUC）来确定受试化合物的降眼压活性。此处所示数据可为其他研究咪唑并[1,2-a]苯并咪唑和嘧啶并[1,2-a]苯并咪唑化合物降眼压作用的研究人员提供基准，并有助于确定这些受试化合物作为降眼压药物的治疗潜力。
