Magalhães Luiza V S, Winckler Maria Isabel B, Bragatti José Augusto, Procianoy Renato S, Silveira Rita C
1 Postgraduate Program in Child and Adolescent Health, UFRGS, Porto Alegre, Brazil.
2 Neuropediatrics Section, HCPA, Porto Alegre, Brazil.
J Child Neurol. 2018 Sep;33(10):659-663. doi: 10.1177/0883073818778468. Epub 2018 Jun 13.
To evaluate the relationship between abnormal early amplitude integrated electroencephalography (EEG) and severe lesions in imaging tests performed during the neonatal period in very low birth weight infants.
An amplitude-integrated EEG was performed in 70 patients with a mean birth weight of 1226 g during the first 48 hours of life. Severe lesions on magnetic resonance imaging (MRI) or ultrasonography (US) during the neonatal period were considered as adverse conditions. Variables were compared using the χ test or analysis of variance. Sensitivity, specificity, and positive likelihood ratio were calculated.
Adverse outcomes were observed in 6 patients. There was a significant relationship ( P < .001) between abnormal amplitude-integrated EEG background and severe lesions on MRI and US. Sensitivity and specificity were 100% and 89%, respectively.
Early amplitude-integrated EEG with moderate/severe abnormalities in the background is associated with severe structural lesions detected in imaging studies and should be considered as an auxiliary screening tool for the detection of neonatal brain lesions in very low birth weight infants.
评估极低出生体重儿出生后早期振幅整合脑电图（EEG）异常与新生儿期影像学检查中严重病变之间的关系。
对70例平均出生体重为1226克的患儿在出生后48小时内进行了振幅整合脑电图检查。新生儿期磁共振成像（MRI）或超声检查（US）中的严重病变被视为不良情况。使用χ检验或方差分析对变量进行比较。计算敏感性、特异性和阳性似然比。
6例患儿出现不良结局。振幅整合脑电图背景异常与MRI和US上的严重病变之间存在显著关系（P <.001）。敏感性和特异性分别为100%和89%。
背景存在中度/重度异常的早期振幅整合脑电图与影像学研究中检测到的严重结构病变相关，应被视为极低出生体重儿新生儿脑病变检测的辅助筛查工具。
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