Dewar D, Jenner P, Marsden C D
Neuroscience. 1985 May;15(1):41-6. doi: 10.1016/0306-4522(85)90121-6.
Unilateral injections of a putative kappa-opiate receptor agonist, ethylketocyclazocine, into the globus pallidus of rats caused dose-dependent ipsiversive circling which was inhibited by prior systemic administration of the opiate receptor antagonist naloxone. Neither a putative delta-opiate receptor agonist ( [D-Ala2, D-Leu5]enkephalin) nor a putative mu-opiate receptor agonist (Tyr-D-Ala-Gly-MePhe-Met(0)-ol) induced circling behaviour after unilateral intrapallidal injection. Bilateral intrapallidal injection of the delta-opiate receptor agonist or the mu-opiate receptor agonist caused an increase in locomotor activity which in both cases was reduced by systemic administration of naloxone. A specific delta-receptor antagonist, (N,N-bisalyl-Tyr-Gly-Gly-psi-(CH2S)-Phe-Leu-OH) had no effect on the increase in locomotor activity caused by the delta-opiate receptor agonist. Bilateral intrapallidal injection of the kappa-opiate receptor agonist had no effect on locomotor activity. It is suggested that different opiate receptor subtypes within the globus pallidus differentially mediate circling and locomotor behaviour.
向大鼠苍白球单侧注射一种假定的κ-阿片受体激动剂乙基酮环唑新，会引起剂量依赖性的同侧旋转，而预先全身性给予阿片受体拮抗剂纳洛酮可抑制这种旋转。单侧苍白球内注射假定的δ-阿片受体激动剂（[D-Ala2, D-Leu5]脑啡肽）或假定的μ-阿片受体激动剂（Tyr-D-Ala-Gly-MePhe-Met(0)-ol）均未诱导出旋转行为。双侧苍白球内注射δ-阿片受体激动剂或μ-阿片受体激动剂会导致运动活性增加，在这两种情况下，全身性给予纳洛酮均可使其降低。一种特异性δ-受体拮抗剂（N,N-双水杨酰-Tyr-Gly-Gly-ψ-(CH2S)-Phe-Leu-OH）对δ-阿片受体激动剂引起的运动活性增加没有影响。双侧苍白球内注射κ-阿片受体激动剂对运动活性没有影响。提示苍白球内不同的阿片受体亚型对旋转和运动行为有不同的介导作用。
