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创建通用语言:在公共卫生领域定义个体化、个性化和精准预防。

Creating a common language: defining individualized, personalized and precision prevention in public health.

机构信息

Department of Health Systems Management and Quality Management for Health Care, Faculty of Public Health, University of Debrecen, Nagyerdei krt. 98, Debrecen, Hungary.

Value Based Healthcare Programme, Department of Primary Care, University of Oxford, Oxford, UK.

出版信息

J Public Health (Oxf). 2018 Dec 1;40(4):e552-e559. doi: 10.1093/pubmed/fdy066.

Abstract

BACKGROUND

Because of the limited success of population-based prevention methods and due to developments in genomic screening, public health professionals and health policy makers are increasingly interested in more individualized prevention strategies. However, the terminology applied in this field is still ambiguous and thus has the potential to create misunderstandings.

METHODS

A narrative literature review was conducted to identify how individualized, personalized and precision prevention are used in research papers and documents. Based on the findings a set of definitions were created that distinguish between these activities in a meaningful way.

RESULTS

Definitions were found only for precision prevention, not for individualized or personalized prevention. The definitions of individualized, personalized and precision medicine were therefore used to create the definitions for their prevention counterparts. By these definitions, individualized prevention consists of all types of prevention that are individual-based; personalized prevention also consists of at least one form of -omic screening; and precision prevention further includes psychological, behavioral and socioeconomic data for each patient.

CONCLUSIONS

By defining these three key terms for different types of individual-based prevention both researchers and health policy makers can differentiate and use them in their proper context.

摘要

背景

由于基于人群的预防方法收效有限,并且由于基因组筛查的发展,公共卫生专业人员和卫生政策制定者越来越关注更个体化的预防策略。然而,该领域应用的术语仍然模糊不清,因此有可能造成误解。

方法

进行了叙述性文献综述,以确定个体化、个性化和精准预防在研究论文和文件中的使用情况。基于这些发现,制定了一套定义,以有意义的方式区分这些活动。

结果

仅为精准预防找到了定义,而不是个体化或个性化预防。因此,使用个体化医学、个性化医学和精准医学的定义来创建其预防对应物的定义。根据这些定义,个体化预防包括所有基于个体的预防类型;个性化预防还包括至少一种形式的组学筛查;而精准预防还包括每位患者的心理、行为和社会经济数据。

结论

通过为不同类型的基于个体的预防定义这三个关键术语,研究人员和卫生政策制定者可以在适当的上下文中区分和使用它们。

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