Magnetic resonance cold pressor test to investigate potential endothelial dysfunction in patients suffering from type 1 diabetes.

BACKGROUND

In its course, diabetes impairs microvascular function through endothelial dysfunction. As the response of myocardial perfusion to sympathetic stimulation through cold is modulated by endothelium-related factors, an incipient endothelial dysfunction might be observed noninvasively by investigation of myocardial perfusion with a cold pressor test (CPT). This approach has been used in clinical MRI previously.

PURPOSE

To assess endothelial function of patients suffering from type 1 diabetes by MR CPT.

STUDY TYPE

Prospective cohort study.

SUBJECTS

Twenty type 1 diabetics and 20 healthy volunteers.

FIELD STRENGTH/SEQUENCE: 3T, dynamic contrast enhanced perfusion (steady-state free precession).

ASSESSMENT

Absolute quantitative myocardial perfusion values at rest and under CPT.

STATISTICAL TESTS

Kolmogorov-Smirnov test to determine normal distribution of the results. T-test for independent samples.

RESULTS

Patients' mean myocardial perfusion was 0.68 cc/g/min at rest and 0.80 cc/g/min during CPT, respective values of 0.81 cc/g/min and 1.36 cc/g/min were found in healthy volunteers. Perfusion values differed significantly for CPT (P < 0.01) but not for resting conditions (P = 0.06).

DATA CONCLUSION

This study demonstrated that endothelial function might be impaired in type 1 diabetes patients. This fosters the thesis that endothelial function may serve as an early biomarker for coronary artery disease in patients with type 1 diabetes while these patients are still clinically asymptomatic.

LEVEL OF EVIDENCE

2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;48:1595-1601.