Roy P, Sugiyama K, Rao C D, Kusari J, Purdy M, Collisson E
Prog Clin Biol Res. 1985;178:589-95.
The degree of relatedness between 4 US serotypes (10, 11, 13 and 17) of bluetongue (BT) virus (BTV) were determined by both oligonucleotide fingerprint analyses of double-stranded (ds) RNA as well as tryptic peptide analyses of viral coded polypeptides. Similar studies were undertaken using different alternate isolates of particular serotypes as well as 2 serotypes (1 and 2) of epizootic hemorrhagic disease (EHD) virus (EHDV), a closely related serogroup of orbiviruses. The results indicate that all BT viruses are genetically related to each other and although EHDV-1 and EHDV-2 originated from a common gene pool, the 2 serogroups, EHDV and BTV, are not genetically interactive.
通过对蓝舌病（BT）病毒（BTV）的4种美国血清型（10、11、13和17）的双链（ds）RNA进行寡核苷酸指纹分析以及对病毒编码多肽进行胰蛋白酶肽分析，确定了它们之间的亲缘关系程度。使用特定血清型的不同替代分离株以及环状病毒密切相关血清群的两种血清型（1和2）的流行性出血病（EHD）病毒（EHDV）进行了类似研究。结果表明，所有BTV病毒在遗传上相互关联，虽然EHDV - 1和EHDV - 2起源于共同的基因库，但EHDV和BTV这两个血清群在遗传上没有相互作用。
