Santoro F M, de la Riva I J
Pharmacol Res Commun. 1985 Apr;17(4):323-30. doi: 10.1016/0031-6989(85)90012-8.
Captopril has a known hypotensive action derived from the inhibition of the converting enzyme (Kininase II). To investigate whether other mechanism may contribute to vasodilation, Na-K ATPase and Mg ATPase activities on ghost red blood cells membranes were examined in the presence of the drug. The results show a stimulation of Mg ATPase activity and an inhibition of Na-K ATPase activity in a concentration dependent manner. The latter action does not seem to be related to a vasodilator effect.
卡托普利具有已知的降压作用，源于对转化酶（激肽酶II）的抑制。为研究是否有其他机制可能导致血管舒张，在有该药物存在的情况下，检测了血影红细胞膜上的钠钾ATP酶和镁ATP酶活性。结果显示，镁ATP酶活性受到刺激，钠钾ATP酶活性受到浓度依赖性抑制。后一种作用似乎与血管舒张效应无关。
