循环 miRNA-302 家族成员作为急性心力衰竭诊断的潜在生物标志物。
Circulating miRNA-302 family members as potential biomarkers for the diagnosis of acute heart failure.
机构信息
Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, PR China.
Division of Cardiology, Keenan Research Center for Biomedical Science at the Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
出版信息
Biomark Med. 2018 Aug;12(8):871-880. doi: 10.2217/bmm-2018-0132. Epub 2018 Jun 14.
AIM
To explore circulating miRNA-302 family members for acute heart failure (AHF) diagnosis.
METHODS
Three groups of subjects, in other words, AHF patients, AHF free patients and healthy controls were recruited. Circulating levels of miR-302 family members were measured and analyzed for AHF diagnosis.
RESULTS
Plasma miR-302s except miR-302f were significantly elevated in AHF patients. MiR-302b-3p had the highest area under curve value of 0.87. There were strong positive correlations between miR-302s and NT-proBNP levels. MiR-302b-3p levels were significantly higher in left ventricular ejection fraction ≤45% and New York Heart Association class IV patients compared with left ventricular ejection fraction >45% and New York Heart Association class II patients, respectively.
CONCLUSION
Levels of circulating miR-302s, miR-302b-3p in particular, could be potentially applied for AHF diagnosis and the differentiation of disease severity.
目的
探讨循环 miRNA-302 家族成员在急性心力衰竭（AHF）诊断中的作用。
方法
招募三组受试者，即 AHF 患者、AHF 无患者和健康对照者。检测并分析循环 miRNA-302 家族成员水平以进行 AHF 诊断。
结果
与健康对照组相比，AHF 患者的血浆 miR-302s（miR-302f 除外）水平显著升高。miR-302b-3p 的曲线下面积值最高，为 0.87。miR-302s 与 NT-proBNP 水平之间存在强正相关。与左心室射血分数（LVEF）>45%和纽约心脏协会（NYHA）心功能分级 II 级患者相比，LVEF≤45%和 NYHA 心功能分级 IV 级患者的 miR-302b-3p 水平显著更高。
结论
循环 miR-302s 的水平，特别是 miR-302b-3p，可能可用于 AHF 的诊断和疾病严重程度的区分。
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