离子液体支持的 N-聚糖核心五糖在 10 克规模上的快速合成。
Ionic-liquid supported rapid synthesis of an N-glycan core pentasaccharide on a 10 g scale.
机构信息
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
出版信息
Org Biomol Chem. 2018 Jul 7;16(25):4720-4727. doi: 10.1039/c8ob01046c. Epub 2018 Jun 14.
A new and efficient Ionic Liquid-Supported Oligosaccharide Synthesis (ILSOS) strategy for an N-linked core pentasaccharide on a 10 g scale is reported. This new ILSOS includes a new spacer for an IL support, a new tagging strategy, and fast, efficient and orthogonal removal of the ionic-liquid support, producing the N-linked core pentasaccharide with direct applicability potential in a short time, with high yield and on a large gram scale.
报道了一种新的、高效的离子液体支持寡糖合成（ILSOS）策略，用于在 10g 规模上合成 N-连接核心五糖。这种新的 ILSOS 包括用于 IL 支持的新间隔基、新的标记策略以及快速、高效和正交的离子液体支持物的去除，可在短时间内以高产率和大克级规模直接获得具有潜在应用价值的 N-连接核心五糖。
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