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茴香的主要成分,反式茴香脑通过调节 Th17/Treg 功能治疗脂多糖诱导的急性肺损伤。

Fennel main constituent, trans‑anethole treatment against LPS‑induced acute lung injury by regulation of Th17/Treg function.

机构信息

School of Chinese Materia Medica, Tianjin University Traditional Chinese Medicine, Tianjin 300193, P.R. China.

Xinjiang Tefeng Pharmaceutical Co., Ltd., Urumqi, Xinjiang 830054, P.R. China.

出版信息

Mol Med Rep. 2018 Aug;18(2):1369-1376. doi: 10.3892/mmr.2018.9149. Epub 2018 Jun 7.

Abstract

Fennel, commonly used in traditional Chinese medicine, is known as Foeniculum vulgare Mill. And its clinical application has been shown to target many biological systems including gastroenterology, endocrinology, gynecology and respiratory. The main constituent of the fennel essential oil is trans‑anethole, which has been described to have anti‑inflammatory and antibacterial activities. The aim of the present study was to define the anti‑inflammatory influence in acute lung injury (ALI)‑bearing mice. For 3 days, ALI‑bearing mice were induced by lipopolysaccharide (LPS) suspension in normal saline (24 mg/kg). On the fourth day, the trans‑anethole was administrated (36.4, 72.8 or 145.6 mg/kg) as well as dexamethasone (5 mg/kg) once per day for 7 consecutive days in mice. Following the completion of drug administration mice were sacrificed. Hematoxylin and eosin staining was performed in the lung paraffin section, for comparisons between monocyte and eosinophil cells in bronchoalveolar lavage fluid. The relative gene expression of interleukin (IL)‑10 and IL‑17 was determined by reverse transcription‑quantitative polymerase chain reaction. These two cytokines and the proportion of T helper 17 (Th17) cells and T regulatory (Treg) cells were determined by flow cytometry. The main constituent of fennel, trans‑anethole, eliminated LPS‑induced histopathological changes, decreased the number of inflammatory cells and resulted in a notable reduction in IL‑17 mRNA expression. In addition, trans‑anethole increased IL‑10 mRNA expression in isolated lung tissues and resulted in a marked elevation in Treg cells and reduction in Th17 cells in spleen tissues. The results of the present study indicated that the main constituent of fennel, trans‑anethole may be an anti‑inflammation component, which influenced the regulation of Th17/Treg responses. Therefore, this medicinal herb may support a healing effect on diseases of inflammatory.

摘要

茴香,常用于中药,被称为 Foeniculum vulgare Mill。其临床应用已被证明针对许多生物系统,包括胃肠病学、内分泌学、妇科学和呼吸科。茴香精油的主要成分是反式茴香脑,据描述具有抗炎和抗菌活性。本研究旨在定义其在急性肺损伤(ALI)小鼠模型中的抗炎作用。通过 LPS 生理盐水悬浮液(24mg/kg),连续 3 天诱导 ALI 模型小鼠。第四天,每天一次给予反式茴香脑(36.4、72.8 或 145.6mg/kg)和地塞米松(5mg/kg),连续 7 天。给药完成后处死小鼠。对肺石蜡切片进行苏木精-伊红染色,比较支气管肺泡灌洗液中单核细胞和嗜酸性粒细胞的数量。通过逆转录-定量聚合酶链反应测定白细胞介素(IL)-10 和 IL-17 的相对基因表达。通过流式细胞术测定这两种细胞因子和 T 辅助 17(Th17)细胞和 T 调节(Treg)细胞的比例。茴香的主要成分反式茴香脑消除了 LPS 诱导的组织病理学变化,减少了炎症细胞的数量,并显著降低了 IL-17 mRNA 的表达。此外,反式茴香脑增加了肺组织中 IL-10 mRNA 的表达,并显著增加了脾脏组织中 Treg 细胞的数量,降低了 Th17 细胞的数量。本研究结果表明,茴香的主要成分反式茴香脑可能是一种抗炎成分,影响 Th17/Treg 反应的调节。因此,这种草药可能对炎症性疾病有治疗作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bdf/6072219/71d224e1fb7e/MMR-18-02-1369-g00.jpg

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