Höfler H, Lammer J, Stammberger H, Gutschi S, Clarici G, Ratschek M
Wien Klin Wochenschr. 1985 Jun 7;97(12):530-4.
A case is described of a jugulotympanic paraganglioma in a 64-year-old woman with extentions down the jugular vein to the clavicle and penetration of the cerebellar fossa. The symptoms, differential diagnosis, therapy and prognosis are discussed on the basis of this case report and compared with the literature. The importance of radiological investigation (e.g. selective angiography and computed tomography) in respect to diagnosis and determination of tumour size is emphasized. The diagnostic value of the immunohistochemical detection of neuron-specific enolase, a neuroendocrine cell marker and S-100 protein is stressed. The most favourable therapy, depending on tumour extension, seems to comprise preoperative embolisation, radical resection and postoperative radiotherapy.
本文描述了一例64岁女性的颈静脉鼓室副神经节瘤，肿瘤沿颈静脉向下延伸至锁骨，并侵入小脑窝。基于该病例报告讨论了症状、鉴别诊断、治疗和预后，并与文献进行了比较。强调了放射学检查（如选择性血管造影和计算机断层扫描）在肿瘤诊断和大小测定方面的重要性。着重指出了免疫组化检测神经内分泌细胞标志物神经元特异性烯醇化酶和S-100蛋白的诊断价值。根据肿瘤的扩展情况，最理想的治疗方法似乎包括术前栓塞、根治性切除和术后放疗。
