Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guizhou 550002, P.R. China.
Department of Interventional Radiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, P.R. China.
Mol Med Rep. 2018 Aug;18(2):1591-1599. doi: 10.3892/mmr.2018.9151. Epub 2018 Jun 11.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer‑associated mortality in the 21st century. microRNA (miR)‑23b has been shown to be involved in the pathogenesis of many cancers, including breast and prostate cancer. However, the role of miR‑23b in HCC remains unclear. The present study revealed a negative correlation between miR‑23b expression in HCC tissues and progression of carcinomas. Compared to normal tissues, miR‑23b expression was significantly downregulated in HCC tissues, whereas the expression of interleukin (IL)‑11 and IL‑11 receptor α (IL‑11Rα) was significantly upregulated, indicating that miR‑23b expression is negatively correlated with IL‑11 and IL‑11Rα expression. In addition, miR‑23b inhibited proliferation and promoted apoptosis of SMMC‑7721 cells. This effect was mediated by IL‑11, which was found to be the direct target of miR‑23b in this study. These results indicated that miR‑23b regulates IL‑11 and IL‑11Rα expression, and might act as an anti‑oncogenic agent in the progression of HCC by directly downregulating IL‑11 expression.
肝细胞癌 (HCC) 是 21 世纪癌症相关死亡的第三大原因。微小 RNA (miR) - 23b 已被证明参与许多癌症的发病机制，包括乳腺癌和前列腺癌。然而，miR-23b 在 HCC 中的作用尚不清楚。本研究揭示了 HCC 组织中 miR-23b 表达与癌进展之间的负相关。与正常组织相比，HCC 组织中 miR-23b 的表达显著下调，而白细胞介素 (IL) -11 和 IL-11 受体 α (IL-11Rα) 的表达显著上调，表明 miR-23b 的表达与 IL-11 和 IL-11Rα 的表达呈负相关。此外，miR-23b 抑制 SMMC-7721 细胞的增殖并促进其凋亡。这种作用是由 IL-11 介导的，研究发现 IL-11 是 miR-23b 在本研究中的直接靶标。这些结果表明，miR-23b 调节 IL-11 和 IL-11Rα 的表达，并可能通过直接下调 IL-11 的表达，作为 HCC 进展中的一种抗癌剂发挥作用。
