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[铒激光治疗女性压力性尿失禁的疗效]

[Outcomes of ER:YAG LASER treatment of stress urinary incontinence in women].

作者信息

Neimark A I, Yakovleva A Yu, Lapii G A

机构信息

Altai State Medical University of Minzdrav of Russia, Barnaul, Russia.

Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.

出版信息

Urologiia. 2018 May(2):20-25.

Abstract

AIM

To evaluate the effectiveness of a new method of treatment for stress urinary incontinence in women using an ER: YAG laser in SMOOTH mode and investigate pathophysiological and pathomorphological changes induced by erbium laser.

MATERIALS AND METHODS

This study comprised 98 women aged 37-63 years, who between 2014 and 2016 were diagnosed with SUI (type 1 and 2a, 2b) and grade 0-2 vaginal prolapse. The treatment was performed with a 2940 nm Er:YAG laser (Fotona, Slovenia) using a SMOOTH mode. Clinical assessment included PFIQ-7 and PISQ-12 questionnaires, uroflowmetry, laser Doppler flowmetry and biopsy of the anterior vaginal wall. The examination was carried out at baseline and 1-2 months after the treatment.

RESULTS

The effectiveness of treatment was 73%. There was no deterioration after the procedure. Analysis of PFIQ-7 and PISQ-12 questionnaires showed that patients with mild incontinence had the greatest difference between pre- and posttreatment results. Uroflowmetry parameters improved in a majority of patients. Results of laser Doppler flowmetry demonstrated the improvement of blood flow in the microvascular bed. An important feature of the vaginal biopsy after laser exposure was an increase in neoangiogenesis.

DISCUSSION

The findings of questionnaires and clinical evaluation of patients with SUI and vaginal prolapse before and after treatment with Er: YAG laser showed high therapeutic effectiveness of this treatment modality.

CONCLUSION

Clinical effectiveness of ER: YAG laser in SMOOTH mode was 73%. Patients with type 1 and 2a SUI and mild or moderate incontinence have the best prognosis after treatment with this method.

摘要

目的

评估采用调Q开关掺铒钇铝石榴石(ER:YAG)激光平滑模式治疗女性压力性尿失禁的新方法的有效性,并研究铒激光诱导的病理生理和病理形态学变化。

材料与方法

本研究纳入了98名年龄在37至63岁之间的女性,她们在2014年至2016年期间被诊断为压力性尿失禁(1型和2a、2b型)以及0至2级阴道脱垂。使用2940纳米的ER:YAG激光(斯洛文尼亚Fotona公司)采用平滑模式进行治疗。临床评估包括盆底功能影响问卷-7(PFIQ-7)和盆底功能影响问卷-12(PISQ-12)、尿流率测定、激光多普勒血流仪检查以及阴道前壁活检。在基线时以及治疗后1至2个月进行检查。

结果

治疗有效率为73%。术后无病情恶化。对PFIQ-7和PISQ-12问卷的分析表明,轻度尿失禁患者治疗前后的结果差异最大。大多数患者的尿流率参数有所改善。激光多普勒血流仪检查结果显示微血管床血流得到改善。激光照射后阴道活检的一个重要特征是新生血管形成增加。

讨论

对压力性尿失禁和阴道脱垂患者在接受ER:YAG激光治疗前后进行问卷调查和临床评估的结果显示,这种治疗方式具有很高的治疗效果。

结论

调Q开关掺铒钇铝石榴石激光平滑模式的临床有效率为73%。1型和2a型压力性尿失禁且轻度或中度尿失禁的患者采用该方法治疗后预后最佳。

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