颈动脉迂曲指数与洛伊斯-迪茨综合征患者早期主动脉根部置换的必要性相关。
Carotid Artery Tortuosity Index Is Associated With the Need for Early Aortic Root Replacement in Patients With Loeys-Dietz Syndrome.
作者信息
Chu Linda C, Haroun Reham R, Beaulieu Robert J, Black James H, Dietz Harry C, Fishman Elliot K
机构信息
From the The Russell H. Morgan Department of Radiology and Radiological Science.
The Department of Surgery, and.
出版信息
J Comput Assist Tomogr. 2018 Sep/Oct;42(5):747-753. doi: 10.1097/RCT.0000000000000764.
OBJECTIVE
This study aimed to determine if carotid arterial tortuosity represents a marker of disease severity in Loeys-Dietz syndrome (LDS).
METHODS
Fifty-four 54 LDS patients (mean age, 17.0 years) who underwent computed tomogram angiography from January 2004 to December 2013 were retrospectively identified. Carotid artery tortuosity index (CATI) was calculated from computed tomogram angiography. Clinical variables were obtained from the medical records. Relationship between CATI and need for aortic root replacement was evaluated with Cox proportional hazard model and Kaplan-Meier analysis.
RESULTS
Higher CATI was associated with the need for aortic root replacement (P < 0.001) in the univariate Cox proportional hazard model. Patients were stratified based on both CATI and aortic root size in Kaplan-Meier analysis, and patients with higher CATI were more likely to require aortic root replacement (P < 0.001) in both aortic root size strata.
CONCLUSION
Increased carotid artery tortuosity is associated with the need for early aortic root replacement in patients with LDS.
目的
本研究旨在确定颈动脉迂曲是否代表洛伊斯-迪茨综合征（LDS）疾病严重程度的一个指标。
方法
回顾性纳入2004年1月至2013年12月期间接受计算机断层血管造影的54例LDS患者（平均年龄17.0岁）。通过计算机断层血管造影计算颈动脉迂曲指数（CATI）。从病历中获取临床变量。采用Cox比例风险模型和Kaplan-Meier分析评估CATI与主动脉根部置换需求之间的关系。
结果
在单变量Cox比例风险模型中，较高的CATI与主动脉根部置换需求相关（P<0.001）。在Kaplan-Meier分析中，根据CATI和主动脉根部大小对患者进行分层，在两个主动脉根部大小分层中，CATI较高的患者更有可能需要主动脉根部置换（P<0.001）。
结论
LDS患者颈动脉迂曲增加与早期主动脉根部置换需求相关。
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