Lu Yun, Gao Wei, Huang Lu-Qi
School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Key Laboratory Breeding Base of Dao-di Herbs, National Resources Center for Chinses Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2018 May;43(9):1806-1811. doi: 10.19540/j.cnki.cjcmm.20180307.004.
miRNA (microRNA) is a kind of important endogenous non-coding small RNA, which mainly regulates the expression of target gene at the post-transcriptional level by splicing and translation inhibition and it plays an important role in the synthesis of plant secondary metabolites, especially for medicinal plants, the secondary metabolites are mostly active ingredients, which are the basis of medicinal effects. It is of great significance to study the biosynthetic pathways and complex regulatory networks of secondary metabolites of medicinal plants.This review introduces the miRNAs related to the synthesis of secondary metabolites in medicinal plants,which focuses on effects of miRNAs on biosynthesis of terpenoids, alkaloids and flavonoids,aiming to provide new ideas for biosynthesis and regulation of secondary metabolites of medicinal plants.
微小RNA（miRNA）是一类重要的内源性非编码小RNA，主要通过剪接和翻译抑制在转录后水平调控靶基因的表达，其在植物次生代谢产物的合成中发挥重要作用。特别是对于药用植物而言，次生代谢产物大多是活性成分，是药效的基础。研究药用植物次生代谢产物的生物合成途径和复杂调控网络具有重要意义。本文综述了与药用植物次生代谢产物合成相关的miRNA，重点阐述了miRNA对萜类、生物碱和黄酮类生物合成的影响，旨在为药用植物次生代谢产物的生物合成及调控提供新思路。
