[Interaction between alcohol-drinking and other factors of lifestyles on the risk of type 2 diabetes mellitus].

OBJECTIVE

To explore the interaction between alcohol-drinking and other factors of lifestyles on the risk of type 2 diabetes mellitus( T2 DM).

METHODS

From June2015 to February 2016, 320 patients diagnosed with T2 DM in Huainan Eastern Hospital and 640 healthy cases at the same time in local medical examination center were randomlychosen to carry out the investigation, the differences between the two groups about demography, alcohol-drinking, smoking, physical activities and dietary habits were compared. Non-conditional logistic regression and generalized multifactor dimensionality reduction( GMDR) were used for statistical analysis.

RESULTS

( 1) Data from logistic regression analysis showed that after adjusting confounding factors, compared with Q1, the intake marks of grains( OR = 0. 310, 95% CI 0. 153-0. 628), vegetables-fruits( OR =0. 444, 95% CI 0. 245-0. 806), milk or dairy products( OR = 0. 510, 95% CI 0. 329-0. 790), beans( OR = 0. 434, 95% CI 0. 212-0. 901), red meat( OR = 0. 461, 95% CI0. 229-0. 926), western food( OR = 0. 223, 95% CI 0. 076-0. 652), sugary drinks( OR = 0. 150, 95% CI 0. 035-0. 643) were Q5 and the BMI less than 24. 0( OR =0. 189, 95% CI 0. 109-0. 329) were protective factors of T2 DM. However, frequent drinking( OR = 3. 936, 95% CI 1. 145-8. 734) and moderate physical activities which were equal to or more than five times per week( OR = 1. 558, 95% CI 1. 013-2. 876)were risk factors of T2 DM. There were multiplied interaction between frequent drinking and intake of grains( Q5)( OR = 0. 852, 95% CI 0. 765-0. 949) or vegetables-fruits( Q5)( OR = 0. 862, 95% CI 0. 757-0. 982) or adequate moderate physical activities( OR = 0. 613, 95% CI 0. 468-0. 803). There were additive interactions between frequent drinking and high intake of red meat or sugary drinks or adequate moderate physical activities. GMDR analysis showed that interaction among sugary drinks, red meat and frequent drinking on the risk of T2 DM may exist( P = 0. 001).

CONCLUSION

Frequent drinking and some other controllable factors have combined effect to increase the risk of T2 DM.