L-leucine increases translation of and in erythroblasts from del(5q) myelodysplastic syndrome patients.
作者信息
Bello Erica, Kerry Jonathan, Singh Shalini, Yip Bon Ham, Kušec Rajko, Killick Sally, Raynaud Sophie, Boultwood Jacqueline, Pellagatti Andrea
机构信息
Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, UK.
Medical Research Council (MRC) Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK.
出版信息
Haematologica. 2018 Nov;103(11):e496-e500. doi: 10.3324/haematol.2018.190447. Epub 2018 Jun 14.
Abstract
摘要
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LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs.LARP1作为mTORC1介导的一类重要mRNA翻译的分子开关发挥作用。
Elife. 2017 Jun 26;6:e25237. doi: 10.7554/eLife.25237.
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Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19.斑马鱼RPS19突变导致的钻石黑范贫血模型中红系细胞蛋白质生成缺陷。
Cell Death Dis. 2014 Jul 24;5(7):e1352. doi: 10.1038/cddis.2014.318.
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Leukemia. 2013 Aug;27(8):1760-3. doi: 10.1038/leu.2013.20. Epub 2013 Jan 22.
5
Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies.5q-综合征及其他核糖体病中氨基酸（L）-亮氨酸对mTOR通路的激活作用。
Adv Biol Regul. 2013 Jan;53(1):8-17. doi: 10.1016/j.jbior.2012.09.002. Epub 2012 Sep 13.
6
Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia.饮食中的 L-亮氨酸可改善 Diamond-Blackfan 贫血小鼠模型的贫血。
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7
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