静脉注射免疫球蛋白治疗一名男孩的难治性癫痫
Intavenous immunoglobulin for the management of intractable epilepsy in a boy.
作者信息
Papadopoulou-Alataki E, Garganis K, Dalpa E, Alataki S, Spilioti M
机构信息
4 Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.
Department of Epilepsy, St. Lukes Hospital, Thessaloniki, Greece.
出版信息
Hippokratia. 2017 Jan-Mar;21(1):55-57.
BACKGROUND
The involvement of the immune system in the pathogenesis of certain types of epilepsy has been supported in the past. The use of intravenous immunoglobulin in the treatment of neurologic diseases has shown a progressive trend over the last years.
CASE REPORT
We report the case of a 9.5-year-old boy with refractory epilepsy who was admitted for investigation of his persistent seizures and severe psychomotor regression. He experienced persistent tonic-clonic over the preceding six months and long lasting atonic seizures since the age of six and did not respond to multiple anticonvulsant drugs. The administration of intravenous immunoglobulin achieved seizure control and cognitive improvement.
CONCLUSION
This case underscores the efficacy of intravenous immunoglobulin in the treatment of refractory epilepsy in children. HIPPOKRATIA 2017, 21(1): 55-57.
背景
过去已有证据支持免疫系统参与某些类型癫痫的发病机制。在过去几年中，静脉注射免疫球蛋白在治疗神经疾病方面呈逐渐发展的趋势。
病例报告
我们报告了一名9.5岁难治性癫痫男孩的病例，该男孩因持续性癫痫发作和严重精神运动发育迟缓入院接受检查。他在之前的六个月里持续出现强直阵挛发作，自六岁起就有长期的失张力发作，对多种抗惊厥药物均无反应。静脉注射免疫球蛋白后实现了癫痫控制和认知改善。
结论
该病例强调了静脉注射免疫球蛋白在治疗儿童难治性癫痫中的疗效。《希波克拉底》2017年，21(1)：55 - 57。
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