脱氧胆酸盐可诱导人血小板和大鼠角膜磷脂酶C对多磷酸肌醇进行优先水解。
Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C.
作者信息
Chung S M, Proia A D, Klintworth G K, Watson S P, Lapetina E G
出版信息
Biochem Biophys Res Commun. 1985 Jun 14;129(2):411-6. doi: 10.1016/0006-291x(85)90166-4.
Deoxycholate promotes phospholipase C degradation of endogenous phosphatidyl[3H]inositol (Pl), phosphatidyl[3H]inositol monophosphate (PIP) and phosphatidyl[3H]inositol bisphosphate (PIP2) in rat cornea and human platelets. Hydrolysis of phosphatidyl[3H]inositol significantly lags polyphospho[3H]inositide degradation. Concomitantly, formation of [3H]inositol monophosphate (IP1) lags behind [3H]inositol bisphosphate (IP2) and [3H]inositol trisphosphate (IP3) production. These results demonstrate that rat cornea and human platelet phospholipase C cause a preferential hydrolysis of the endogenous polyphosphoinositides rather than phosphatidylinositol.
脱氧胆酸盐可促进大鼠角膜和人血小板中内源性磷脂酰[3H]肌醇（PI）、磷脂酰[3H]肌醇单磷酸酯（PIP）和磷脂酰[3H]肌醇二磷酸酯（PIP2）的磷脂酶C降解。磷脂酰[3H]肌醇的水解显著滞后于多磷酸[3H]肌醇磷脂的降解。同时，[3H]肌醇单磷酸酯（IP1）的形成滞后于[3H]肌醇二磷酸酯（IP2）和[3H]肌醇三磷酸酯（IP3）的产生。这些结果表明，大鼠角膜和人血小板中的磷脂酶C会优先水解内源性多磷酸肌醇磷脂而非磷脂酰肌醇。
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