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脱氧胆酸盐可诱导人血小板和大鼠角膜磷脂酶C对多磷酸肌醇进行优先水解。

Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C.

作者信息

Chung S M, Proia A D, Klintworth G K, Watson S P, Lapetina E G

出版信息

Biochem Biophys Res Commun. 1985 Jun 14;129(2):411-6. doi: 10.1016/0006-291x(85)90166-4.

DOI:10.1016/0006-291x(85)90166-4
PMID:2990455
Abstract

Deoxycholate promotes phospholipase C degradation of endogenous phosphatidyl[3H]inositol (Pl), phosphatidyl[3H]inositol monophosphate (PIP) and phosphatidyl[3H]inositol bisphosphate (PIP2) in rat cornea and human platelets. Hydrolysis of phosphatidyl[3H]inositol significantly lags polyphospho[3H]inositide degradation. Concomitantly, formation of [3H]inositol monophosphate (IP1) lags behind [3H]inositol bisphosphate (IP2) and [3H]inositol trisphosphate (IP3) production. These results demonstrate that rat cornea and human platelet phospholipase C cause a preferential hydrolysis of the endogenous polyphosphoinositides rather than phosphatidylinositol.

摘要

脱氧胆酸盐可促进大鼠角膜和人血小板中内源性磷脂酰[3H]肌醇（PI）、磷脂酰[3H]肌醇单磷酸酯（PIP）和磷脂酰[3H]肌醇二磷酸酯（PIP2）的磷脂酶C降解。磷脂酰[3H]肌醇的水解显著滞后于多磷酸[3H]肌醇磷脂的降解。同时，[3H]肌醇单磷酸酯（IP1）的形成滞后于[3H]肌醇二磷酸酯（IP2）和[3H]肌醇三磷酸酯（IP3）的产生。这些结果表明，大鼠角膜和人血小板中的磷脂酶C会优先水解内源性多磷酸肌醇磷脂而非磷脂酰肌醇。

相似文献

1
Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C.脱氧胆酸盐可诱导人血小板和大鼠角膜磷脂酶C对多磷酸肌醇进行优先水解。
Biochem Biophys Res Commun. 1985 Jun 14;129(2):411-6. doi: 10.1016/0006-291x(85)90166-4.
2
Studies of endogenous polyphosphoinositide hydrolysis in human platelet membranes. Evidence that polyphosphoinositides remain inaccessible to phosphodiesterase in the native membrane.人血小板膜内源性多磷酸肌醇水解的研究。多磷酸肌醇在天然膜中对磷酸二酯酶仍不可接近的证据。
Biochim Biophys Acta. 1986 Feb 12;875(2):147-56. doi: 10.1016/0005-2760(86)90163-3.
3
Activation of phospholipase C in platelets by platelet activating factor and thrombin causes hydrolysis of a common pool of phosphatidylinositol 4,5-bisphosphate.血小板活化因子和凝血酶激活血小板中的磷脂酶C，导致共同池中的磷脂酰肌醇4,5-二磷酸水解。
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Activation of phospholipase C associated with isolated rabbit platelet membranes by guanosine 5'-[gamma-thio]triphosphate and by thrombin in the presence of GTP.在存在鸟苷5'-[γ-硫代]三磷酸（GTP）的情况下，鸟苷5'-[γ-硫代]三磷酸和凝血酶对与兔血小板分离膜相关的磷脂酶C的激活作用。
Biochem J. 1987 Apr 15;243(2):457-65. doi: 10.1042/bj2430457.
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PAF-induced activation of polyphosphoinositide-hydrolyzing phospholipase C in cerebral cortex.
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Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glands.多磷酸肌醇而非磷脂酰肌醇的分解代谢是毒蕈碱激动剂刺激大鼠腮腺中肌醇磷脂代谢的原因。
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The affinities of human platelet and Acanthamoeba profilin isoforms for polyphosphoinositides account for their relative abilities to inhibit phospholipase C.人类血小板和棘阿米巴肌动蛋白结合蛋白亚型对多磷酸肌醇的亲和力决定了它们抑制磷脂酶C的相对能力。
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The decrease in phosphatidylinositol 4,5-bisphosphate in ADP-stimulated washed rabbit platelets is not primarily due to phospholipase C activation.在二磷酸腺苷（ADP）刺激的洗涤兔血小板中，磷脂酰肌醇4,5-二磷酸的减少并非主要由于磷脂酶C的激活。
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Effect of desipramine on inositol phosphate formation and inositol phospholipids in rat brain and human platelets.
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Effect of antidepressants and neuroleptics on phosphoinositide metabolism in human platelets.抗抑郁药和抗精神病药对人血小板中磷酸肌醇代谢的影响。
J Pharmacol Exp Ther. 1991 Mar;256(3):1010-8.

引用本文的文献

1
The formation of lysophosphatidylinositol phosphate in human platelet microsomes.人血小板微粒体中溶血磷脂酰肌醇磷酸的形成。
Lipids. 1987 Mar;22(3):144-7. doi: 10.1007/BF02537292.
2
Carbachol and histamine stimulation of guanine-nucleotide-dependent phosphoinositide hydrolysis in rat brain cortical membranes.卡巴胆碱和组胺对大鼠脑皮质膜中鸟嘌呤核苷酸依赖性磷酸肌醇水解的刺激作用。
Biochem J. 1989 Jul 1;261(1):29-35. doi: 10.1042/bj2610029.
3
Guanine nucleotide- and muscarinic agonist-dependent phosphoinositide metabolism in synaptoneurosomes from cerebral cortex of immature rats.
未成熟大鼠大脑皮质突触神经小体中鸟嘌呤核苷酸和毒蕈碱激动剂依赖性磷酸肌醇代谢
Neurochem Res. 1992 Nov;17(11):1133-41. doi: 10.1007/BF00967291.