Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
Chem Commun (Camb). 2018 Jun 28;54(53):7314-7317. doi: 10.1039/c8cc03037e.
We developed highly bright and stable far-red emissive AIEdots by using a new kind of click-functional PEG grafted amphiphilic polymer to coat hydrophobic AIE-active polymers (PDFDP). Furthermore, an anti-HER2 recombinant fully human antibody was produced and conjugated on the AIEdots via metal-free click chemistry to fabricate in vivo tumor-targeting nanoprobes.
我们通过使用一种新型点击功能的 PEG 接枝两亲聚合物来包覆疏水性 AIE 活性聚合物 (PDFDP)，从而开发出高亮度和稳定的远红发射 AIEdots。此外，我们还制备了一种抗 HER2 的重组全人源抗体，并通过无金属点击化学将其偶联到 AIEdots 上，以构建体内肿瘤靶向纳米探针。
