Kansy Benjamin, Lang Stephan
Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Essen, Universität Duisburg-Essen.
Laryngorhinootologie. 2018 Mar;97(S 01):S3-S47. doi: 10.1055/s-0043-121594. Epub 2018 Mar 22.
In the field of immunotherapy, essential progress was achieved over the past years partially demonstrating long lasting therapeutic responses in different tumor entities. A better understanding of the interactions between the tumor and the immune system as well as the integration of immunotherapeutic approaches into clinical routine were the foundations for this development. The different approaches intervene on multiple levels of the immune response and directly or indirectly mount the patient's own immune defense against tumor cells. Immunotherapeutic approaches are represented by cytokine therapies, vaccinations, the use of oncolytic viruses and monoclonal antibody therapies as well as adoptive cell transfer strategies.
在免疫治疗领域,过去几年取得了重大进展,部分证明了在不同肿瘤实体中具有持久的治疗反应。对肿瘤与免疫系统之间相互作用的更好理解以及免疫治疗方法融入临床常规是这一发展的基础。不同的方法在免疫反应的多个层面进行干预,直接或间接地增强患者自身针对肿瘤细胞的免疫防御。免疫治疗方法包括细胞因子疗法、疫苗接种、溶瘤病毒的使用、单克隆抗体疗法以及过继性细胞转移策略。