Obernikhin S, Yaglova N, Tsomartova D, Torbek V, Ivanova M
1Federal State Budgetary Institution Research Institute of Human Morphology, Moscow; 2Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, Russia.
Georgian Med News. 2018 May(278):138-146.
Chromaffin cells of adrenal medulla have traditionally been considered as modified sympathetic neurons. However, the results of recent studies indicate the need to revise this concept. The article reviews recent findings in origin and ontogeny of adrenal chromaffin cells and transcriptional and posttranscriptional regulation of developmental processes. The article summarizes data on transcriptional control of chromaffin cells proliferation and maturation and participation of microRNA in regulation of chromaffin and sympathetic neuronal phenotype gene expression.
肾上腺髓质的嗜铬细胞传统上被认为是经过修饰的交感神经元。然而，最近的研究结果表明有必要修正这一概念。本文综述了肾上腺嗜铬细胞起源与个体发育以及发育过程中转录和转录后调控的最新研究发现。文章总结了嗜铬细胞增殖和成熟的转录控制以及微小RNA在嗜铬细胞和交感神经元表型基因表达调控中的参与情况的数据。
