Department of Biomedical Sciences, School of Public Health, University at Albany, SUNY, Albany, NY 12201-2002, USA.
Wadsworth Center, New York State Department of Health, Albany, NY 12201-2002, USA.
Pathog Dis. 2018 Jul 1;76(5). doi: 10.1093/femspd/fty048.
Mycobacterium tuberculosis (Mtb) is one of the most successful microbial pathogens, and currently infects over a quarter of the world's population. Mtb's success depends on the ability of the bacterium to sense and respond to dynamic and hostile environments within the host, including the ability to regulate bacterial metabolism and interactions with the host immune system. One of the ways Mtb senses and responds to conditions it faces during infection is through the concerted action of multiple cyclic nucleotide signaling pathways. This review will describe how Mtb uses cyclic AMP, cyclic di-AMP and cyclic di-GMP to regulate important physiological processes, and how these signaling pathways can be exploited for the development of novel thereapeutics and vaccines.
结核分枝杆菌（Mtb）是最成功的微生物病原体之一，目前感染了世界上超过四分之一的人口。Mtb 的成功取决于其感知和响应宿主内动态和恶劣环境的能力，包括调节细菌代谢和与宿主免疫系统相互作用的能力。Mtb 感知和响应感染过程中面临的条件的一种方式是通过多种环核苷酸信号通路的协同作用。这篇综述将描述 Mtb 如何使用环 AMP、环二 AMP 和环二 GMP 来调节重要的生理过程，以及这些信号通路如何被用于开发新的治疗方法和疫苗。
