Prasad K, O'Neil C L, Bharadwaj B
Cardiovasc Res. 1985 Jul;19(7):406-10. doi: 10.1093/cvr/19.7.406.
Prazosin has been used in the treatment of congestive heart failure. It is, however, not known whether prazosin gives only haemodynamic benefit or if it also produces a decrease in the cardiac sarcolemmal Na+-K+-ATPase which has been reported to be increased in the failing heart. The present investigation deals with the effect of 3 months of prazosin treatment in dogs with 3 months of induced mitral insufficiency (MI) on the sarcolemmal Na+-K+-ATPase activity. The dogs were divided into four groups each comprising of five dogs. A--normal; B--3 months of MI; C--6 months of MI; D--3 months of prazosin treatment after 3 months of MI. Three months of MI produced a decrease in the dp/dt and an increase in the end-diastolic pressure of left ventricle but no change in the index of left ventricular contractility and cardiac index. Also there was no change in the sarcolemmal Na+-K+-ATPase. There was a significant decrease in the index of left ventricular contractility and cardiac index and an increase in the LVEDP associated with a significant increase in the left ventricular sarcolemmal Na+-K+-ATPase at 6 months of MI. Sarcolemmal Mg2+-ATPase of both ventricles increased after 6 months of MI the significance of which is not known as yet. There was no change in the sarcolemmal Na+-K+-ATPase of the nonfailing right ventricle. Prazosin treatment prevented the deterioration of the left ventricular contractility and function and also prevented the increase in the sarcolemmal Na+-K+-ATPase observed in failing heart.(ABSTRACT TRUNCATED AT 250 WORDS)
哌唑嗪已被用于治疗充血性心力衰竭。然而，尚不清楚哌唑嗪是否仅带来血流动力学益处，或者它是否还会使心肌肌膜钠钾ATP酶减少，据报道该酶在衰竭心脏中会增加。本研究探讨了对诱导性二尖瓣关闭不全（MI）3个月的犬进行3个月哌唑嗪治疗对肌膜钠钾ATP酶活性的影响。犬被分为四组，每组五只。A组——正常；B组——MI 3个月；C组——MI 6个月；D组——MI 3个月后进行3个月哌唑嗪治疗。MI 3个月使左心室dp/dt降低，舒张末期压力升高，但左心室收缩性指数和心脏指数无变化。肌膜钠钾ATP酶也无变化。MI 6个月时，左心室收缩性指数和心脏指数显著降低，左心室舒张末期压力升高，同时左心室肌膜钠钾ATP酶显著增加。MI 6个月后，两个心室的肌膜镁ATP酶均增加，其意义尚不清楚。未衰竭的右心室肌膜钠钾ATP酶无变化。哌唑嗪治疗可防止左心室收缩性和功能恶化，还可防止衰竭心脏中观察到的肌膜钠钾ATP酶增加。（摘要截短至250字）
