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丝裂霉素、阿霉素和顺铂联合用于晚期肉瘤的II期研究

Phase II study of a combination of mitomycin, doxorubicin and cisplatin in advanced sarcomas.

作者信息

Edmonson J H, Long H J, Richardson R L, Creagan E T, Green S J

出版信息

Cancer Chemother Pharmacol. 1985;15(2):181-2. doi: 10.1007/BF00257535.

DOI:10.1007/BF00257535
PMID:2990751
Abstract

In all 63 patients were treated monthly with a combination of mitomycin, doxorubicin, and cisplatin, and 27 (43%) experienced objective regression of their advanced sarcomas during a 3-month trial. The observed regression rate is numerically higher than any previously observed at our institution.

摘要

63名患者均每月接受丝裂霉素、阿霉素和顺铂联合治疗，在为期3个月的试验中，27名（43%）患者的晚期肉瘤出现了客观缓解。观察到的缓解率在数值上高于我们机构之前观察到的任何缓解率。

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本文引用的文献

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Cyclophosphamide, doxorubicin, and cisplatin combined in the treatment of advanced sarcomas.
Med Pediatr Oncol. 1983;11(5):319-21. doi: 10.1002/mpo.2950110504.
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Failure of bleomycin to improve the therapeutic effects of a combination of cyclophosphamide, doxorubicin, and cisplatin (CAP) in advanced sarcomas.
Med Pediatr Oncol. 1984;12(4):264-6. doi: 10.1002/mpo.2950120411.
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A comparative clinical trial evaluating the combination of adriamycin, DTIC, and vincristine, the combination of actinomycin D, cyclophosphamide, and vincristine, and a single agent, methyl-CCNU, in advanced sarcomas.一项比较性临床试验，评估阿霉素、氮烯咪胺和长春新碱联合用药，放线菌素D、环磷酰胺和长春新碱联合用药，以及单一药物甲基环己亚硝脲治疗晚期肉瘤的效果。
Cancer Treat Rep. 1976 Sep;60(9):1385-7.