Mills I H, Chakravarty B, Brownlee A, Lee G, Mortimer W
Clin Exp Hypertens A. 1985;7(5-6):783-92. doi: 10.3109/10641968509077227.
Human urine contains a small molecular weight natriuretic substance and similar material isolated from the kidney inhibits Na/K ATPase. Such action on smooth muscle in blood vessels would cause contraction. Human urinary natriuretic material caused contraction of the smooth muscle in the rat anococcygeus muscle and this activity correlated with its natriuretic activity. Known vasoactive substances could not explain the activity of the natriuretic factor when tested on the anococcygeus muscle. The best correlation with blood pressure of the patient was with the log of the ratio of natriuretic activity divided by the kallikrein excretion. A normotensive woman with severe renal failure had very high kallikrein excretion as well as increased natriuretic activity and her data fitted the same correlation as the hypertensives' data.
人尿中含有一种小分子量的利钠物质，从肾脏分离出的类似物质可抑制钠钾ATP酶。这种对血管平滑肌的作用会导致收缩。人尿利钠物质可引起大鼠肛门尾骨肌平滑肌收缩，且这种活性与其利钠活性相关。在对肛门尾骨肌进行测试时，已知的血管活性物质无法解释利钠因子的活性。与患者血压的最佳相关性是利钠活性除以激肽释放酶排泄量的比值的对数。一名患有严重肾衰竭的血压正常女性激肽释放酶排泄量非常高，利钠活性也增加，她的数据与高血压患者的数据符合相同的相关性。
