追寻骨侵蚀的清晰认识：自噬体相关蛋白 1 在骨 Paget 病中的作用。
A quest for clarity in bone erosion: The role of sequestosome 1 in Paget's disease of bone.
机构信息
From the Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan 49503.
From the Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan 49503
出版信息
J Biol Chem. 2018 Jun 15;293(24):9542-9543. doi: 10.1074/jbc.H118.003689.
Alterations in the gene are a putative cause of Paget's disease of bone, yet results are conflicting about how these mutations impact osteoclasts, the cell type believed to be the main pathological contributor. In this issue of JBC, Zach provide important new evidence that the protein encoded by , p62, negatively regulates osteoclastogenesis and demonstrate that aged p62-deficient mice develop bone phenotypes similar to those of Paget's disease. These findings help to clarify the role of this important protein and present new opportunities to interrogate bone biology.
该基因的改变被认为是引起 Pagets 骨病的一个潜在原因，但这些突变如何影响破骨细胞的结果存在争议，破骨细胞被认为是主要的病理性贡献细胞。在本期 JBC 中，Zach 提供了重要的新证据，表明 编码的蛋白 p62 负调节破骨细胞生成，并证明老年 p62 缺陷型小鼠表现出类似于 Pagets 病的骨表型。这些发现有助于阐明该重要蛋白的作用，并为研究骨生物学提供了新的机会。
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