School of Life Science, National Taiwan Normal University, Taipei, Taiwan.
School of Life Science, National Taiwan Normal University, Taipei, Taiwan.
Chem Biol Interact. 2018 Aug 1;291:137-143. doi: 10.1016/j.cbi.2018.06.011. Epub 2018 Jun 13.
Therapy by targeting cancer stem cells (CSCs) is an eligible method to eradicate malignant human tumors. A synthetic triepoxide derivative, teroxirone, was reported effective against the growth of human lung cancer cells by injuring cellular mitochondria functions. And yet it remains unclear if the residual but malicious CSCs can be effectively dissipated following treatment. The current study further affirmed that teroxirone inhibited the propagation of CSCs as enriched from NSCLC cells by inducing p53 that lead to ultimate apoptosis. More evidence supported that the reduced stemness of the spheroids was associated with apoptotic death. The results consolidate the notion that teroxirone is a viable and effective therapeutic agent for eradicating human lung cancer.
针对癌症干细胞 (CSC) 的治疗是一种消除恶性人类肿瘤的可行方法。一种合成的三环氧衍生物，teroxirone，据报道可通过损伤细胞线粒体功能来有效抑制人类肺癌细胞的生长。然而，尚不清楚在治疗后残留的但恶性的 CSC 是否可以被有效消除。本研究进一步证实，teroxirone 通过诱导 p53 抑制 NSCLC 细胞中富集的 CSC 的增殖，最终导致细胞凋亡。更多的证据表明，球体的干细胞特性降低与细胞凋亡死亡有关。这些结果证实了 teroxirone 是一种可行且有效的治疗人类肺癌的药物。
