Department of Oncology, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201900, China.
Department of Oncology, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201900, China.
Biochimie. 2018 Sep;152:6-13. doi: 10.1016/j.biochi.2018.06.007. Epub 2018 Jun 21.
Small ubiquitin-like modifier (SUMOylation) is a reversible post-translational modification, which plays important roles in numerous biological processes. SUMO could be covalently attached to target proteins in an isopeptide bond manner that occurs via a lysine ε-amino group on the target proteins and the glycine on SUMO C-terminus. This covalent binding could affect the subcellular localization and stability of target proteins. SUMO modification can be reversed by members of the Sentrin/SUMO-specific proteases (SENPs) family, which are highly evolutionarily conserved from yeast to human. SENP2, a member of the SENPs family, mainly plays a physiological function in the nucleus. SENP2 can promote maturity of the SUMO and deSUMOylate for single-SUMO modified or poly-SUMO modified proteins. SENP2 can affect the related biological processes through its peptidase activity or the amino terminal transcriptional repression domain. It plays important roles by inhibiting or activating some molecular functions. Therefore, the research achievements of SENP2 are reviewed in order to understand its related functions and the underlying molecular mechanisms and provide a clue for future research on SENP2.
小泛素样修饰物（SUMOylation）是一种可逆的翻译后修饰，在许多生物过程中发挥着重要作用。SUMO 可以通过靶蛋白赖氨酸 ε-氨基和 SUMO C 末端甘氨酸之间的异肽键共价连接到靶蛋白上。这种共价结合可以影响靶蛋白的亚细胞定位和稳定性。SUMO 修饰可以通过 Sentrin/SUMO 特异性蛋白酶（SENPs）家族成员逆转，该家族成员从酵母到人高度保守。SENP2 是 SENPs 家族的一员，主要在核内发挥生理功能。SENP2 可以促进 SUMO 的成熟，并对单 SUMO 修饰或多 SUMO 修饰蛋白进行去 SUMOylation。SENP2 可以通过其肽酶活性或氨基末端转录抑制结构域影响相关的生物学过程。它通过抑制或激活某些分子功能发挥重要作用。因此，综述了 SENP2 的研究成果，以了解其相关功能和潜在的分子机制，并为 SENP2 的进一步研究提供线索。
