Lewis R A
Chest. 1985 Aug;88(2 Suppl):98S-102S. doi: 10.1378/chest.88.2_supplement.98s.
The likelihood that the leukotriene products derived from the 5-lipoxygenase pathway mediate aspects of obstructive airways diseases is strongly suggested by their documented capacities to effect airway spasmogenicity, airway hyperreactivity, tissue edema formation, mucus secretion, and tissue infiltration by leukocytes. That the various leukotriene components of SRS-A have unique receptors on responding tissues and are recoverable from airway surfaces in several inflammatory lung diseases and that several resident and infiltrating cell types have significant potential for leukotriene biosynthesis lend further support to their postulated pathobiologic roles. To fulfill Koch's postulates for proof of leukotrienes' etiologic role, it remains to be shown that inhibition of their biosynthesis or specific antagonism at their end-organ receptors can greatly ameliorate these disease states.
源自5-脂氧合酶途径的白三烯产物介导阻塞性气道疾病的各个方面，这一可能性被其已被证实的影响气道痉挛性、气道高反应性、组织水肿形成、黏液分泌以及白细胞组织浸润的能力所强烈暗示。SRS-A的各种白三烯成分在反应组织上具有独特的受体，并且在几种炎症性肺部疾病的气道表面可被检测到，而且几种驻留和浸润细胞类型具有产生白三烯的巨大潜力，这些都进一步支持了它们假定的病理生物学作用。为了满足科赫法则以证明白三烯的病因学作用，仍有待证明抑制其生物合成或在其终末器官受体处进行特异性拮抗能够极大地改善这些疾病状态。
