Daniëls Liesbeth, Naesens Maarten, Bosmans Jean-Louis, Abramowicz Daniel, Nagler Evi, Van Laecke Steven, Peeters Patrick, Kuypers Dirk, Emonds Marie-Paule
Histocompatibility and Immunogenetics Laboratory (HILA), Red Cross-Flanders, Mechelen, Belgium.
Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium; Department of Microbiology and Immunology, KU Leuven, University of Leuven, Belgium.
Transpl Immunol. 2018 Oct;50:55-59. doi: 10.1016/j.trim.2018.06.006. Epub 2018 Jun 15.
Since the advent of kidney transplantation a key strategy for maximising graft survival by avoiding allorecognition has been to minimise HLA mismatching between donor and recipient. As HLA antibodies are now recognised as being specific for epitopes and donor-recipient HLA mismatch at the amino acid level can now be determined, HLA epitope mismatch load could be a better predictor for dnDSA development than classical HLA antigen mismatch calculation. This hypothesis has been investigated by other studies and the aim of our multicentre study was to confirm this observation in our population. Two algorithms, HLAMatchmaker and PIRCHE-II, were used to determine the HLA epitope mismatch load between donor and recipient. We have shown a significant association between the number of HLA epitope mismatches and the development of dnDSA and we have confirmed the earlier observations.
自肾移植出现以来，通过避免同种异体识别来最大化移植物存活的关键策略一直是尽量减少供体和受体之间的HLA错配。由于现在已认识到HLA抗体对表位具有特异性，并且现在可以确定供体 - 受体HLA在氨基酸水平上的错配，与经典的HLA抗原错配计算相比，HLA表位错配负荷可能是预测dnDSA发生的更好指标。其他研究已经对这一假设进行了调查，我们多中心研究的目的是在我们的人群中证实这一观察结果。使用两种算法HLAMatchmaker和PIRCHE-II来确定供体和受体之间的HLA表位错配负荷。我们已经表明HLA表位错配的数量与dnDSA的发生之间存在显著关联，并且我们已经证实了早期的观察结果。
