Sylus Angel Mercy, Nandeesha Hanumanthappa, Sridhar Magadi Gopalakrishna, Chitra Thyagaraju, Sreenivasulu Karli
Department of Biochemistry and Obstetrics and Gynecology, JIPMER, Puducherry, India.
Department of Biochemistry and Obstetrics and Gynecology, JIPMER, Puducherry, India.
Eur J Obstet Gynecol Reprod Biol. 2018 Sep;228:27-31. doi: 10.1016/j.ejogrb.2018.06.007. Epub 2018 Jun 8.
Matrix metalloproteinase-9, Nitric oxide and inflammation plays a role in the pathogenesis of poly cystic ovary syndrome (PCOS). Even though these parameters are altered in PCOS, the effect of clomiphene citrate on them has not been studied till date. The present study was done to assess the effect of clomiphene citrate on matrix metalloproteinase-9, nitric oxide and interleukin-10 levels in women with PCOS.
72 women diagnosed with PCOS were enrolled in the study. Matrix metalloproteinase-9, nitric oxide and interleukin-10 levels were compared at baseline and after three weeks following Clomiphene citrate treatment.
Clomiphene citrate increases both nitric oxide (p = 0.03) and interleukin-10 (p < 0.001) levels and reduces matrix metalloproteinase-9 levels (p < 0.001) in women with PCOS. It also improves the ovulation rate (52.8%) and clinical pregnancy rate (19.4%) in PCOS. Also there was a significant reduction in matrix metalloproteinase-9 levels in both the ovulatory (p < 0.001) and conceived groups (p = 0.024) compared to non ovulatory and non conceived group. There was no difference in nitric oxide and interleukin-10 levels in ovulatory and conceived groups compared to non ovulatory and non conceived group.
We conclude that clomiphene citrate increases the levels of nitric oxide and interleukin-10 and decreases the matrix metalloproteinase - 9 levels and improves the ovulation rate and clinical pregnancy rate in PCOS.
基质金属蛋白酶-9、一氧化氮和炎症在多囊卵巢综合征（PCOS）的发病机制中起作用。尽管这些参数在PCOS中发生了改变，但迄今为止，氯米芬对它们的影响尚未得到研究。本研究旨在评估氯米芬对PCOS女性基质金属蛋白酶-9、一氧化氮和白细胞介素-10水平的影响。
72名被诊断为PCOS的女性纳入本研究。在基线时以及氯米芬治疗三周后，比较基质金属蛋白酶-9、一氧化氮和白细胞介素-10水平。
氯米芬可提高PCOS女性的一氧化氮水平（p = 0.03）和白细胞介素-10水平（p < 0.001），并降低基质金属蛋白酶-9水平（p < 0.001）。它还可提高PCOS的排卵率（52.8%）和临床妊娠率（19.4%）。此外，与未排卵和未受孕组相比，排卵组（p < 0.001）和受孕组（p = 0.024）的基质金属蛋白酶-9水平均显著降低。与未排卵和未受孕组相比，排卵组和受孕组的一氧化氮和白细胞介素-10水平无差异。
我们得出结论，氯米芬可提高一氧化氮和白细胞介素-10水平，降低基质金属蛋白酶-9水平，并提高PCOS的排卵率和临床妊娠率。
